CoQ10 finds its way into the top 11 because of its benefits across the health spectrum. Athletes benefit from its performance boosting mitochondrial effects while our chronically ill patients find it helpful for several different conditions. CoQ10 is found in a number of mitochondrial combinations for the chronically fatigued, assists in lowering lipid peroxides (signs of oxidative stress and cellular aging), strengthens failing hearts, lessens migraines, and more.
Energy/Mitochondrial: For those suffering from mitochondrial dysfunction CoQ10 combines with carnitine and alpha lipoic acid (and other nutrients) to restore a measure of function.
Anti-oxidant: Post-strenuous exercise is a great time for taking CoQ10. This nutrient lowers lipid peroxides which are the results of oxidative stress on the fats in cell membranes.
Heart: While studies show mixed results, many show an increase in ejection fraction or increased exercise ability for heart failure patients. For everyone taking a statin, this nutrient is critical since these lipid lowering medications deplete your body of CoQ10.
Migraines: Probably due to its ability to improve the mitochondria in nerve cells, CoQ10 helps many patients with chronic migraines. It must be dosed high enough.
Fibromyalgia/Chronic Fatigue: Those suffering from fibromyalgia and chronic fatigue seem to benefit from taking CoQ10 with its mitochondrial assisting abilities.
How to Get the Benefits of CoQ10: CoQ10 may be consumed by meat lovers and vegetarians in the following foods: pork, beef, chicken, organ meats, and fatty fish OR spinach, broccoli, cauliflower, oranges, avocados, strawberries, lentils, sesame seeds, pistachios and peanuts. Supplementation may be necessary for those dealing with chronic health conditions.
Energy & Mitochondrial Support:
J Am Diet Assoc. 2003 Aug;103(8):1029-38.
Nutritional cofactor treatment in mitochondrial disorders.
Marriage B1, Clandinin MT, Glerum DM.
Anti-oxidant:
Biofactors. 2016 Nov 12;42(6):612-622. doi: 10.1002/biof.1297. Epub 2016 May 19.
Short-term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial.
Sarmiento A, Diaz-Castro J, Pulido-Moran M, Moreno-Fernandez J, Kajarabille N, Chirosa I, Guisado IM, Javier Chirosa L, Guisado R, Ochoa JJ
BMC Res Notes. 2014 Jul 4;7:427. doi: 10.1186/1756-0500-7-427.
Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans.
Onur S, Niklowitz P, Jacobs G, Nöthlings U, Lieb W, Menke T, Döring F
Biochim Biophys Acta. 1995 May 24;1271(1):195-204.
Biochemical, physiological and medical aspects of ubiquinone function.
Ernster L1, Dallner G.
Heart & Cardiovascular:
. Am J Clin Nutr. 2013 Feb;97(2):268-75. doi: 10.3945/ajcn.112.040741. Epub 2012 Dec 5.
Effect of coenzyme Q₁₀ supplementation on heart failure: a meta-analysis.
Fotino AD1, Thompson-Paul AM, Bazzano LA.
BMC Cardiovasc Disord. 2017 Jul 24;17(1):196. doi: 10.1186/s12872-017-0628-9.
Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials.
Lei L1, Liu Y2.
JACC Heart Fail. 2014 Dec;2(6):641-9. doi: 10.1016/j.jchf.2014.06.008. Epub 2014 Oct 1.
The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial.
Mortensen SA1, Rosenfeldt F2, Kumar A3, Dolliner P4, Filipiak KJ5, Pella D6, Alehagen U7, Steurer G4, Littarru GP8; Q-SYMBIO Study Investigators.
Clin Investig. 1993;71(8 Suppl):S134-6.
Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study.
Morisco C1, Trimarco B, Condorelli M.
Statins: Qu, J Am. Heart Association 2018.
Migraines:
European Journal of Integrative Medicine
Volume 21, August 2018, Pages 70-76 Clinical trial
The effect of Coenzyme Q10 supplementation on serum levels of lactate, pyruvate, matrix metalloproteinase 9 and nitric oxide in women with migraine. A double blind, placebo, controlled randomized clinical trial
Elyas, Nattagh-Eshtivania,
Monireh, Dahrib, Mazyar, Hashemilarc, Ali, Tarighat-Esfanjanid
Neurology. 2005 Feb 22;64(4):713-5.
Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial.
Sándor PS1, Di Clemente L, Coppola G, Saenger U, Fumal A, Magis D, Seidel L, Agosti RM, Schoenen J.
Acta Neurol Belg. 2017 Mar;117(1):103-109. doi: 10.1007/s13760-016-0697-z. Epub 2016 Sep 26.
Effectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: an open-label, add-on, controlled trial.
Shoeibi A, Olfati N, Soltani Sabi M, Salehi M, Mali S, Akbari Oryani M.
Fibromyalgia:
CNS Neurosci Ther. 2017 Feb;23(2):188-189. doi: 10.1111/cns.12668. Epub 2017 Jan 4.
Effect of Coenzyme Q10 on Psychopathological Symptoms in Fibromyalgia Patients.
Alcocer-Gómez E, Culic O, Navarro-Pando JM, Sánchez-Alcázar JA, Bullón P.
Front Biosci (Landmark Ed). 2014 Jan 1;19:619-33.
Clinical applications of coenzyme Q10.
Garrido-Maraver J, Cordero MD, Oropesa-Avila M, Vega AF, de la Mata M, Pavon AD, Alcocer-Gomez E, Calero CP, Paz MV, Alanis M, de Lavera I,
Sanctuary Functional Medicine, under the direction of Dr Eric Potter, IFMCP MD, provides functional medicine services to Nashville, Middle Tennessee and beyond. We frequently treat patients from Kentucky, Alabama, Mississippi, Georgia, Ohio, Indiana, and more… offering the hope of healthier more abundant lives to those with chronic illness.