In addition to genetic variations causing differing toxin sensitivities, different combinations of toxins often synergize. Chronic infections and life stressors can also amplify or modify the intensity of the toxin’s effects on a person. Even with unfavorable mold detoxification genetics, some may not manifest symptoms if amplifying factors remain absent. The exposome, or the collective set of toxins in a person’s environment, may trigger mold illness when organic compounds or heavy metals tip over the immune system. It is basically a “1+1=3” situation. Either toxin alone might not trigger illness, but the two together pack a devastating punch.