Allergies & Food Sensitivities:
Bischoff SC. Food allergy and eosinophilic gastroenteritis and colitis. Curr Opin Allergy Clin Immunol. 2010;10:238–245. doi: 10.1097/ACI.0b013e32833982c3.
Autoimmune disease:
Megan Ciara Smyth; Intestinal permeability and autoimmune diseases, Bioscience Horizons: The International Journal of Student Research, Volume 10, 1 January 2017, hzx015, https://doi.org/10.1093/biohorizons/hzx015
Qinghui Mu, Jay Kirby, Christopher M. Reilly and Xin M. Luo. Front. Immunol., 23 May 2017 | https://doi.org/10.3389/fimmu.2017.00598
Leaky Gut As a Danger Signal for Autoimmune Diseases
Scher JU, Abramson SB. The microbiome and rheumatoid arthritis. Nat Rev Rheumatol. 2011;7:569–578.
General:
Arrieta, M C et al. “Alterations in intestinal permeability” Gut vol. 55,10 (2006): 1512-20. …. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856434/
| Alterations in intestinal permeability – PubMed Central (PMC)www.ncbi.nlm.nih.govThe goal of this review is to describe barrier function of the intestine, the structure of the tight junction, methods to evaluate intestinal permeability, and most importantly the relevance of abnormal permeability to disease. |
A Bischoff, Stephan C et al. “Intestinal permeability–a new target for disease prevention and therapy” BMC gastroenterology vol. 14 189. 18 Nov. 2014, doi:10.1186/s12876-014-0189-7 …. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253991/
| Intestinal permeability – a new target for disease prevention and therapy – PubMed Central (PMC)www.ncbi.nlm.nih.govData are accumulating that emphasize the important role of the intestinal barrier and intestinal permeability for health and disease. However, these terms are poorly defined, their assessment is a matter of debate, and their clinical significance is not clearly established. |
Kelly, John R et al. “Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders” Frontiers in cellular neuroscience vol. 9 392. 14 Oct. 2015, doi:10.3389/fncel.2015.00392 …. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604320/
| Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders – PubMed Central (PMC)www.ncbi.nlm.nih.govBrain-gut-microbiota axis. Bidirectional signaling between the gut and the brain is regulated at neural, endocrine, and immune levels. These pathways are under the influence of the gut microbiota and together, they comprise the brain-gut-microbiota axis (Grenham et al., 2011).A cardinal function of the gut microbiota is the development and maintenance of the intestinal barrier across the … |
Miller AL
Alternative Medicine Review : a Journal of Clinical Therapeutic [01 Aug 1999, 4(4):239-248] Glutamine therapy
IBS;
Barbara G, Cremon C, Carini G, Bellacosa L, Zecchi L, De Giorgio R, Corinaldesi R, Stanghellini V. The immune system in irritable bowel syndrome. J Neurogastroenterol Motil. 2011;17:349–359. doi: 10.5056/jnm.2011.17.4.349.
Brown PM, Drossman DA, Wood AJ, Cline GA, Frazier KS, Jackson JI, Bronner J, Freiman J, Zambrowicz B, Sands A, Gershon MD. The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel syndrome. Gastroenterology. 2011;141:507–516. doi: 10.1053/j.gastro.2011.05.005.
Bühner S, Li Q, Vignali S, Barbara G, De Giorgio R, Stanghellini V, Cremon C, Zeller F, Langer R, Daniel H, Michel K, Schemann M. Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome. Gastroenterology. 2009;137:1425–1434. doi: 10.1053/j.gastro.2009.07.005.
Camilleri M, Lasch K, Zhou W. Irritable bowel syndrome: methods, mechanisms, and pathophysiology: the confluence of increased permeability, inflammation, and pain in irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol. 2012;303:G775–G785. doi: 10.1152/ajpgi.00155.2012.
Coëffier M, Gloro R, Boukhettala N, Aziz M, Lecleire S, Vandaele N, Antonietti M, Savoye G, Bôle-Feysot C, Déchelotte P, Reimund JM, Ducrotté P. Increased proteasome-mediated degradation of occludin in irritable bowel syndrome. Am J Gastroenterol. 2010;105:1181–1188. doi: 10.1038/ajg.2009.700.
Cremon C, Carini G, Wang B, Vasina V, Cogliandro RF, De Giorgio R, Stanghellini V, Grundy D, Tonini M, De Ponti F, Corinaldesi R, Barbara G. Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome. Am J Gastroenterol. 2011;106:1290–1298. doi: 10.1038/ajg.2011.86.
Martínez C, Lobo B, Pigrau M, Ramos L, González-Castro AM, Alonso C, Guilarte M, Guilá M, de Torres I, Azpiroz F, Santos J, Vicario M. Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier. Gut. 2013;62:1160–1168. doi: 10.1136/gutjnl-2012-302093.
Piche T, Barbara G, Aubert P, Bruley des Varannes S, Dainese R, Nano JL, Cremon C, Stanghellini V, De Giorgio R, Galmiche JP, Neunlist M. Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators. Gut. 2009;58:196–201. doi: 10.1136/gut.2007.140806.
Vivinus-Nébot M, Dainese R, Anty R, Saint-Paul MC, Nano JL, Gonthier N, Marjoux S, Frin-Mathy G, Bernard G, Hébuterne X, Tran A, Theodorou V, Piche T. Combination of allergic factors can worsen diarrheic irritable bowel syndrome: role of barrier defects and mast cells. Am J Gastroenterol. 2012;107:75–81. doi: 10.1038/ajg.2011.315.
Metabolic Syndromes:
Amar J, Chabo C, Waget A, Klopp P, Vachoux C, Bermúdez-Humarán LG, Smirnova N, Bergé M, Sulpice T, Lahtinen S, Ouwehand A, Langella P, Rautonen N, Sansonetti PJ, Burcelin R. Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol Med. 2011;3:559–572. doi: 10.1002/emmm.201100159.
Cani PD, Delzenne NM. Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota. Curr Opin Pharmacol. 2009;9:737–743. doi: 10.1016/j.coph.2009.06.016.
de Munter JS, Hu FB, Spiegelman D, Franz M, van Dam RM. Whole grain, bran, and germ intake and risk of type 2 diabetes: a prospective cohort study and systematic review. PLoS Med. 2007;4:e261. doi: 10.1371/journal.pmed.0040261.
Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature. 2006;444:1022–1023. doi: 10.1038/4441022a.
Park Y, Subar AF, Hollenbeck A, Schatzkin A. Dietary fiber intake and mortality in the NIH-AARP diet and health study. Arch Intern Med. 2011;171:1061–1068. doi: 10.1001/archinternmed.2011.18.
Qin J, Li Y, Cai Z, Li S, Zhu J, Zhang F, Liang S, Zhang W, Guan Y, Shen D, Peng Y, Zhang D, Jie Z, Wu W, Qin Y, Xue W, Li J, Han L, Lu D, Wu P, Dai Y, Sun X, Li Z, Tang A, Zhong S, Li X, Chen W, Xu R, Wang M, Feng Q, et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature. 2012;490:55–60. doi: 10.1038/nature11450.
Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444:1027–1031. doi: 10.1038/nature05414.
Mycotoxins and GI Health:
Liew, Winnie-Pui-Pui and Sabran Mohd-Redzwan. “Mycotoxin: Its Impact on Gut Health and Microbiota” Frontiers in cellular and infection microbiology vol. 8 60. 26 Feb. 2018, doi:10.3389/fcimb.2018.00060
J Toxicol Environ Health B Crit Rev. 2017;20(5):249-275. doi: 10.1080/10937404.2017.1326071. Epub 2017 Jun 21.
Impact of mycotoxins on the intestine: are mucus and microbiota new targets?
Robert H, Payros D, Pinton P, Théodorou V, Mercier-Bonin M, Oswald IP. https://www.ncbi.nlm.nih.gov/pubmed/28636450
Neurologic:
Gastroenterol Clin North Am. 2017 Mar;46(1):77-89. doi: 10.1016/j.gtc.2016.09.007. Epub 2017 Jan 4.
The Microbiome-Gut-Brain Axis in Health and Disease.
Dinan TG, Cryan JF.
Curr Neurol Neurosci Rep. 2017 Oct 17;17(12):94. doi: 10.1007/s11910-017-0802-6.
Microbiota-Brain-Gut Axis and Neurodegenerative Diseases.
Quigley EMM
Saulnier, Delphine M et al. “The intestinal microbiome, probiotics and prebiotics in neurogastroenterology” Gut microbes vol. 4,1 (2013): 17-27.
Biol Psychiatry. 2013 Nov 15;74(10):720-6. doi: 10.1016/j.biopsych.2013.05.001. Epub 2013 Jun 10.
Psychobiotics: a novel class of psychotropic.
Dinan TG, Stanton C, Cryan JF.
Psychosom Med. 2017 Oct;79(8):920-926. doi: 10.1097/PSY.0000000000000519.
Brain-Gut-Microbiota Axis and Mental Health.
Dinan TG1, Cryan JF.
Polycystic Ovary Syndrome
Guo, Yanjie et al. “Association between Polycystic Ovary Syndrome and Gut Microbiota” PloS one vol. 11,4 e0153196. 19 Apr. 2016, doi:10.1371/journal.pone.0153196
Sex, Microbes, and Polycystic Ovary Syndrome
Varykina G. Thackray
Trends Endocrinol Metab. 2019 Jan; 30(1): 54–65. Published online 2018 Nov 29. doi: 10.1016/j.tem.2018.11.001
Jahan, Sarwat et al. “Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical study” Journal of ovarian research vol. 11,1 26. 3 Apr. 2018, doi:10.1186/s13048-018-0400-5
Eur J Endocrinol. 2015 Jan;172(1):29-36. doi: 10.1530/EJE-14-0589. Epub 2014 Oct 21.
Serum zonulin is elevated in women with polycystic ovary syndrome and correlates with insulin resistance and severity of anovulation.
Zhang D, Zhang L, Yue F, Zheng Y, Russell R.
WEBSITES SUPPORT:
WebMD believes it —https://www.webmd.com/digestive-disorders/features/leaky-gut-syndrome#1
Harvard believes it — https://www.health.harvard.edu/blog/leaky-gut-what-is-it-and-what-does-it-mean-for-you-2017092212451
Sanctuary Functional Medicine, under the direction of Dr Eric Potter, IFMCP MD, provides functional medicine services to Nashville, Middle Tennessee and beyond. We frequently treat patients from Kentucky, Alabama, Mississippi, Georgia, Ohio, Indiana, and more... offering the hope of healthier more abundant lives to those with chronic illness.
