Immune Cells Wear Watches


       How do they make armbands small enough to fit on the immune cells wrists?  Wait, they don’t have wrists…. Anyway, my point is that research is uncovering the mechanisms by which CD8 immune cells react differently during different times of the day. 

            A team of researchers led by Nicolas Cermakian, PhD, of the Douglas Research Centre, and Nathalie Labrecque, PhD, of the Maisonneuve-Rosemont Hospital Research Centre reported research describing how CD8 immune cells respond differently to invaders based on time of day sensed on a clock gene.  Given the role of CD8 cells in vaccine response and cancer immunology, many more researchers are likely to pursue this with further studies.

Until they determine how these immune clocks work, we will keep recommending good sleep patterns for all our patients or working to restore their dysfunctional sleep.  Just another means of helping our patients move towards a healthier, more abundant life.


Original Article:

Chloé C. Nobis, Geneviève Dubeau Laramée, Laura Kervezee, Dave Maurice De Sousa, Nathalie Labrecque, Nicolas Cermakian. The circadian clock of CD8 T cells modulates their early response to vaccination and the rhythmicity of related signaling pathways. Proceedings of the National Academy of Sciences, 2019; 201905080 DOI: 10.1073/pnas.1905080116


Thanks to Science Daily:

McGill University. “Biological clock influences immune response efficiency.” ScienceDaily. ScienceDaily, 24 September 2019. <>.

Sanctuary Functional Medicine, under the direction of Dr Eric Potter, IFMCP MD, provides functional medicine services to Nashville, Middle Tennessee and beyond. We frequently treat patients from Kentucky, Alabama, Mississippi, Georgia, Ohio, Indiana, and more... offering the hope of healthier more abundant lives to those with chronic illness.

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